The focus of our laboratory is to investigate the role of non-coding RNAs (microRNAs and novel small/long non-coding RNAs), epigenetics and epitranscriptomics in skeletal muscle stem cell biology, cardiac muscle biology, muscle regeneration, and muscle degenerative diseases including Duchenne Muscular Dystrophy (DMD) and DMD-associated cardiomyopathy. DMD is a fatal X-linked childhood muscle degenerative disease. The progressive skeletal muscle wasting leads to cardiomyopathy and other secondary complications. The children affected by DMD become restricted to wheelchairs within the first decade of their lives and die within the third. There is no effective treatment available yet for this devastating disease. The development of a successful therapy for DMD has been significantly hindered due to the lack of a complete understanding of the key myogenic processes and DMD pathophysiology at the cellular and molecular level. The existing knowledge of the regulation of gene expression in myogenic processes remains inadequate. We have been particularly studying different modes of posttranscriptional gene regulation in the myogenic processes to elucidate the intricate molecular networks of myogenesis. We use a variety of cutting edge molecular cell biology, stem cell biology, genetic, epigenetic and epitranscriptomic techniques, and animal models to understand muscle physiology and pathophysiology at the cellular and molecular level. Our aim is to understand the fundamental molecular mechanism of muscle development and to devise new therapeutic and diagnostic platforms for DMD and related muscle degenerative diseases.
We are looking for talented students and postdocs. Please contact Bijan Dey.
Bijan K Dey, PhD
Principal Investigator, The RNA Institute
Adjunct Assistant Professor, Department of Biological Sciences
University at Albany, State University of New York (SUNY)
Life Sciences Research Building Room LS 2098
1400 Washington Avenue, Albany, NY 12222
The path to studying microRNAs in diseases will be easier and cheaper, thanks to a new method developed by a team led by Halvorsen and Dey.
The American Heart Association (AHA) has awarded its distinguished Scientist Development Grant to Dr. Dey for the development of new therapies to treat DMD.
Scientist Bijan Dey could soon offer hope to young patients with a rare form of muscular dystrophy.
University of Virginia researchers have taken a significant step forward in their efforts to use stem cells to block vision loss caused by diabetic retinopathy.