Dr. Shi and his lab create and apply molecular devices to understand and control biological processes in vivo and in real time. One set of molecular devices being developed is RNA-based reagents and aptamers, from which, self-assembling supramolecular aggregates and synthetic gene circuits are generated and used to study and modulate protein functions. In addition to target validation, this type of “genetic applets” has the potential of being utilized directly as therapeutic agents.

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